THROBSTOP-R
Description
Description
Sumatriptan + Naproxen (Fixed-Dose Combination)
Drug Class: Triptan + NSAID
Purpose: Acute treatment of migraine attacks
Components & Mechanism
| Component | Action | Effect |
|---|---|---|
| Sumatriptan (5-HT?B/1D agonist) |
Vasoconstricts cranial blood vessels, inhibits neuropeptide release | Rapid relief of migraine pain + associated symptoms |
| Naproxen Sodium (NSAID) |
Inhibits COX-1 & COX-2 ? ? prostaglandin synthesis | Reduces inflammation and prolongs pain relief |
Clinical Advantages
- Faster onset of pain relief
- Longer duration of action
- Lower recurrence within 24 hours
- Less need for rescue medication
Indications
- Acute migraine attacks (with or without aura)
- Patients with recurrence after triptan monotherapy
Dosage (Adults)
- Typical tablet: Sumatriptan 85 mg + Naproxen 500 mg
- Administration: Take at onset of migraine
- Max: 2 tablets in 24 hrs (?2 hrs apart)
- Not for prophylaxis (preventive use)
Common Side Effects
| Side Effect | Sumatriptan | Naproxen | Combination Risk |
|---|---|---|---|
| GI irritation / Gastritis | Present | Common | Moderate |
| Chest tightness / flushing | Occasional | Rare | Low |
| Dizziness | Occasional | Occasional | Moderate |
| Cardiovascular risk | Rare | Present | Caution advised |
Contraindications
- Cardiovascular disease (IHD, stroke, uncontrolled hypertension)
- Peptic ulcer disease / GI bleeding
- NSAID hypersensitivity or aspirin-induced asthma
- Severe liver or kidney impairment
- Pregnancy & lactation (use caution)
Clinical Note: Especially useful in patients with migraines that recur within 24 hrs of triptan use, since naproxen prolongs effect.
