GIOTENSIN-AM

Telmisartan + Amlodipine Combination

Category

• Antihypertensive Combination
• ARB (Angiotensin II Receptor Blocker) + Calcium Channel Blocker (CCB)

Mechanism of Action

• Telmisartan: Blocks angiotensin II at AT1 receptors ? prevents vasoconstriction & reduces aldosterone ? lowers blood pressure.
• Amlodipine: Inhibits L-type calcium channels in vascular smooth muscle ? causes vasodilation ? reduces peripheral vascular resistance.

Together, they complement each other: Telmisartan relaxes vessels via RAAS inhibition, and Amlodipine widens arteries directly. This provides better and sustained BP control than either drug alone.

Indications

• Hypertension (when single drug is insufficient)
• Patients needing multi-mechanism BP control
• May help reduce cardiovascular event risk in high-risk patients

Dosage Forms

• 40 mg Telmisartan + 5 mg Amlodipine
• 80 mg Telmisartan + 5 mg Amlodipine

Benefits of Combination

• Dual mechanism gives additive BP lowering
• Reduces BP variability over 24 hours
• Lower risk of dose-related side effects compared to high-dose monotherapy
• Amlodipine’s ankle edema risk is reduced when combined with Telmisartan

Precautions

• Avoid in pregnancy
• Monitor potassium & kidney function
• Use caution in severe hepatic impairment
• Gradually adjust dose to avoid excessive BP drop